Simple exploration of 932-22-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.

Example 30; 4-Chloro-5-(3-cyclobutyl-2,3,4,5-tetrahydro-lH-benzo[d]azepin-7-yloxy)-2-methyl-2H- pyridazin-3-one; General synthesis of Example 30; Step 1.; To a round-bottom flask was added 4,5-dichloro-2H-pyridazin-3-one (10.0 g, 60.6 mmol), potassium carbonate (16.8 g, 121.2 mmol), iodomethane (4.0 mL, 64.3 mmol), and acetonitrile (80 mL). The reaction mixture was heated at reflux for 12 h and was cooled to room temperature. The reaction was filtered and the filtrate was concentrated. The residue was purified by column chromatography (CH2Cl2) to give 8.21 g (76%) of 4,5- dichoro-2-methyl-2H-pyridazin-3-one. 1HNMR (400 MHz, OMSO-d6) 5 8.18 (s, IH), 3.70 (s, 3H) ; MS (m/z) = 179 (M + l)., 932-22-9

The synthetic route of 932-22-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CEPHALON, INC.; WO2009/142732; (2009); A2;,
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