35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2H-tetrazole (1.83 1 g, 26.1 mmol) in DMF (30 ml) was added Cs2CO3 (8.52 g, 26.1 mmol) at 0 C. The resulting solution was stirred at 0 C for 15 mm followed by addition of 6-chloropyridazine-3-carbonitrile (Liu, et al., I Med. Chem. 2007, 50, 3086-3 100)(3.04 g, 21.79 mmol). The resulting solution was stirred at rt for 30 mm, then heated at 90 C for30mm. The mixture was cooled to rt, and partitioned between EtOAc and sat. NaHCO3. The organic layer was washed with sat.NaHCO3 three times, dried over Na2504, and concentrated. The residue was stirred with DCM. The solid was collectted by filtration to give the title compound.
35857-89-7, The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; BISWAS, Dipshikha; DING, Fa-Xiang; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; PASTERNAK, Alexander; SUZUKI, Takao; VACCA, Joseph; XU, Shouning; WO2015/105736; (2015); A1;,
Pyridazine – Wikipedia
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