1120-95-2, 3-Chloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 4-4 (Trans)-8-({[6-(2-methylphenyl)-3-pyridazinyl]amino}methyl)-3-(3-pyridazinyl)-1-oxa-3-azaspiro[4.5]decan-2-one dihydrochloride (Trans)-8-({[6-(2-methylphenyl)-3-pyridazinyl]amino}methyl)-1-oxa-3-azaspiro[4.5]decan-2-one (Intermediate 45, 40.0 mg, 0.114 mmol), 3-chloropyridazine (prepared according to WO/0107416, 13 mg, 0.114 mmol), copper(I) iodide (21.62 mg, 0.114 mmol), trans-1,2-diaminocyclohexane (0.027 ml, 0.227 mmol), K3PO4 (72.3 mg, 0.341 mmol) were collected in a closed vial and suspended in 1,4-dioxane (4 ml). The resulting mixture was stirred at 130 C. for 4 hours. Solvent was removed under vacuum. The crude was taken up with DCM (8 ml) and filtered over a separating tube. The resulting solution was purified with Biotage SP1, over a 12M NH2 Varian cartridge, eluding with a gradient of cyclohexane and ethyl acetate. The title compound was eluted with EtOAc and recovered as colourless oil. Then it was further purified with Biotage SP1, over a 12M NH2 Varian cartridge, eluding with a gradient of cyclohexane and ethyl acetate to recover the title compound as nearly chemically pure colourless oil (30 mg). 1H NMR (400 MHz, CDCl3): delta 8.97 (dd, 1H), 8.58 (dd, 1H), 7.52 (dd, 1H), 7.45-7.41 (m, 1H), 7.36-7.29 (m, 4H), 6.75 (m, 1H), 4.92 (brs, 2H), 3.45 (t, 2H), 2.43 (s, 3H), 2.15-1.11 (m, 9H)., 1120-95-2
The synthetic route of 1120-95-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Biagetti, Matteo; Contini, Stefania Anna; Genski, Thorsten; Guery, Sebastien; Leslie, Colin Philip; Mazzali, Angelica; Pizzi, Domenica Antonia; Sabbatini, Fabio Maria; Seri, Catia; US2009/203705; (2009); A1;,
Pyridazine – Wikipedia
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