With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5096-73-1,6-Chloropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.
5096-73-1, The compound (100 mg, 0.631 mmol) obtained in Example 11a was dissolved in methylene chloride (6 mL), triethylamine (0.105 mL, 0.757 mmol) and pivaloyl chloride (78 muL, 0.631 mmol) were added under ice cooling, and the mixture was stirred at room temperature for 15 minutes. A solution of tert-butyl methyl[3-(methylamino)propyl]carbamate (described in J. Med. Chem. 1990, 33, 97-101) (128 mg, 0.631 mmol) in methylene chloride (3 mL) was added dropwise under ice cooling, and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (methylene chloride:methanol = 20:1, v/v) to give a crude Boc compound (202 mg).
The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2409977; (2012); A1;,
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