372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (20.7 g, 100 mmol),2,4-dimethoxybenzylamine (17.5 g, 105 mmol)And diisopropylethylamine (25.84 g, 200 mmol) were dissolved in acetonitrile (800 mL).After stirring at room temperature for 15 hours,The solvent was removed under reduced pressure, and the residue was dispersed in water (1 L).After stirring for 30 minutes, it was filtered. The filtered solid was washed with water (300 mL) and cold acetonitrile (300 mL) in this order.The target product 6-chloro-4-((2,4-dimethoxybenzyl) amino) pyridazine-3-carboxylic acid methyl ester 31a (26 g, white solid) was obtained,Yield: 76%., 372118-01-9
The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
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