34584-69-5, 3,6-Dichloro-4,5-dimethylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To the solution of 3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5′-carboxylic acid methyl ester (250 mg, 1.07 mmol) in NMP (5 mL) is added 3,6-dichloro-4,5-dimethyl-pyridazine (237 mg, 1.33 mmol) and TEA (446 mul, 3.21 mmol), the reaction mixture is stirred at 190¡ã C. for 60 min. Water is added to the mixture and extracted with EtOAc. The combined organic layers are washed with water, brine, dried over Na2SO4, filtered and concentrated. The crude product is purified by HPLC, (acetonitrile/water: 10percent95percent with 3percent 1-propanol) to give white powder (165 mg, 43percent).1H-NMR (400 MHz, DMSO-d6) delta=8.69 (s, 1H), 8.44 (s, 1H), 3.92 (t, J=5.0 Hz, 4H), 3.83 (s, 3H), 3.27 (m, 4H), 2.41 (s, 3H), 2.32 (s, 3H).MS (m/z, MH+) meas. 363., 34584-69-5
The synthetic route of 34584-69-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Novartis AG; US2010/41663; (2010); A1;,
Pyridazine – Wikipedia
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