35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tert- butyl piperidin-4-yl carbamate (1.40 g, 6.99 mmol) and 6- chloropyridazine-3-carbonitrile (967.4 mg, 6.93 mmol) in EtOH (20 mL) was added Et3N (976.2 mg, 9.65 mmol). The reaction mixture was stirred at rt overnight and then concentrated in vacuo. The residue was stirred with a mixture of EtOH and water (10 mL/l mL) for 0.5 hour and filtered to give the title compound as a pale brown solid (2.13 g, yield 100%).MS (ESI, pos. ion) m/z: 304.2 [M+H]+;1H NMR (400 MHz, DMSO-^e) d (ppm): 7.83 (d, J= 9.7 Hz, 1H), 7.36 (d, J= 9.7 Hz, 1H), 6.89 (d, J= 7.3 Hz, 1H), 4.40 (d, J= 13.4 Hz, 2H), 3.67 – 3.56 (m, 1H), 3.24 – 3.12 (m, 2H), 1.84 (d, J= 10.1 Hz, 2H), 1.39 (s, 9H), 1.35 – 1.31 (m, 2H)., 35857-89-7
35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyridazine – Wikipedia
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