6082-66-2, 3,4,6-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6082-66-2
1.2. 2-[4-(3,6-dichloropyridazin-4-yl)-piperazin-1-yl]-ethanol In a 50mL round bottom flask, 9.18g (0.05 mol) of 3,4,6-trichloro-pyridazine, 5.30g (0.05 mol) of anhydrous sodium carbonate and 20mL of N,N-dimethylacetamide (DMA) were added, stirred at room temperature, then 6.54g (0.05mol) of 2-(piperazin-1-yl)-ethanol (dissolved in 10ml DMA) was added dropwise slowly, stirred overnight, filtered on the next day. 100mL of distilled water was added into the filter cake and stirred, then filtered again to obtain 10.20g of a white solid, yield: 73.6%, m.p.139~ 141C. 1H-NMR(400MHz, CDCl3) deltappm: 2.57(br, 1H), 2.66~2.68(t, 2H, J=5.12Hz), 2.73~2.76(t, 4H, J=4.76Hz), 3.36~3.38(t, 4H, J=4.52Hz), 3.68~3.71(t, 2H, J=5.04Hz), 6.88(s, 1H). 13C-NMR(400MHz, DMSO-d6) deltappm: 155.14, 149.43, 148.70, 116.64, 60.00, 58.49, 52.44, 48.90. EI-MS m/e: 276.1[M+, 100], 280{[M+4]+, 100}, 245.0, 207.1, 175.1, 100.1, 70.1.
The synthetic route of 6082-66-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; EP1900735; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem