With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88497-27-2,3-Amino-6-bromopyridazine,as a common compound, the synthetic route is as follows.
88497-27-2, In a three-neck flask, 3-biphenylboronic acid (5 g, 25 mmol), 3-amino-6-bromopyridazine (4.3 g, 25 mmol), potassium carbonate (6.9 g, 50 mmol), tetrakistriphenylphosphine palladium (0.3) was added. g), tetrahydrofuran (30 mL) and water (15 mL), heating under reflux under nitrogen for 5 hours, extraction with dichloromethane, drying, concentration, purification of the crude product by column chromatography gave the product as 4.6 g, 74% yield.
As the paragraph descriping shows that 88497-27-2 is playing an increasingly important role.
Reference£º
Patent; Shanghai Daoyi Chemical Technology Co., Ltd.; Huang Jinhai; Su Jianhua; (22 pag.)CN107793436; (2018); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem