17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Ethyl 2-(6-(6-bromopyridazin-3-yl)-l-oxo-2-(2,2,2-trifluoroethyl)-l,2,3,4- tetrahydronaphthalen-2-vDacetate (22A) : Pd(dppf)Cl2 (0.154 g, 0.21 mmol) was added to a solution of 3,6-dibromo pyridazine (1 g, 4.2 mmol) in 16 mL of 1,4 dioxane-H20 (3: 1) mixture under argon atmosphere, followed by cesium carbonate (4.1 1 g, 12.61 mmol) and 1H (1.85 g, 4.2 mmol). The mixture was degassed for 5 min. The reaction mixture was refluxed for 2 h, solvent was removed under reduced pressure, and the residue was partitioned between ethyl acetate and water. The separated organic layer was dried over sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by flash chromatography using 10% ethyl acetate in hexane to afford the title compound (0.8 g, 40%) as a solid. lU NMR (300 MHz, CDC13): delta 8.19 (d, J= 8.1 Hz, 1H), 8.06 (s, 1H), 7.90 (dd, J = 2.1 Hz, J2 = 8.7 Hz, 1H), 7.77 (s, 2H), 4.14 (q, J= 6.9 Hz, 2H), 3.16 (t, J= 6.0 Hz, 2H), 2.95 – 2.82 (m, 2H), 2.69 – 2.57 (m, 2H), 2.53 – 2.32 (m, 2H), 1.24 (t, J= 7.2 Hz, 3H). ESI-MS m/z: 471 (M+H)+.
17973-86-3, 17973-86-3 3,6-Dibromopyridazine 248852, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE LLC; CHEUNG, Mui; TANGIRALA, Raghuram, S.; WO2014/74761; (2014); A2;,
Pyridazine – Wikipedia
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