6082-66-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6082-66-2,3,4,6-Trichloropyridazine,as a common compound, the synthetic route is as follows.
To a solution of 3,4,6-trichloro-pyridazine (59) (364 mg, 2 mmol ) and piperidin- 4-yl-methanol (35) (253 mg, 2.2 mmol ) in DMSO (5 mL) was added Et3N (404 mg, 4 mmol). The reaction mixture was stirred at 100C overnight. The reaction mixture was diluted with water, extracted with EtOAc (30 mL x 3). The combined organic extracts were washed with water (30 mL) and brine (30 mL), dried over Na2S04 and filtered. The filtrate was evaporated in vacuo and the residue was purified by flash column chromatography on silica gel to give [l-(3,6- dichloro-pyridazin-4-yl)-piperidin-4-yl]-methanol (60) (292.3 mg, 1.12 mmol, yield 75.99%)0 ESI-MS (M+l): 262 calc. for Ci0Hi3Cl2N3O 261.
As the paragraph descriping shows that 6082-66-2 is playing an increasingly important role.
Reference£º
Patent; AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge; WO2011/143365; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem