35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 46; 6-r(3R,4S)-3-(2,4-Difluorophenv?-4-(f(3S,4S)-3,4-dimethoxy-4-phenylpiperidin-1-vncarbonyl|pyrrolidin- 1 yllPyridazin-3-carbonitrile; To a solution of the product from preparation 15 (87.0 mg, 0.19 mmol) in tetrahydrofuran (2 mL) was added 2-chloro-5-cyanopyridazine (52.0mg, 0.37 mmol), N,N-diisopropylethylamine (0.1 mL, 0.56 mmol) and the reaction mixture was heated at reflux for 1.5 h. The solvent was removed and the residue was purified by column chromatography (silica) eluting with pentane:ethyl acetate to afford the title compound (84 mg, 84%). 1H NMR (CD3OD, 400 MHz) ,delta 1.15-1.22 and1.28 and 1.73-1.82 (m, s, m, 1 H), 1.95 and 2.04-2.13 and 2.48-2.51 and 2.60-2.62 (d, 3xm, 3H), 2.95-3.12 (m, 2xs, 7H), 3.33-3.45 (m, 1 H), 3.70- 3.93 and 4.03-4.33 and 4.47-4.51 (4xm, 7H), 6.98-7.11 (m, 3H), 7.24-7.32 (m, 2H), 7.35-7.40 (m, 2H), 7.45-7.59 (m, 2H), 7.68-7.72 (m, 1 H); LRMS (APCI+) 534 [MH+], (ESI+) 534 [MH+].
35857-89-7, The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER LIMITED; WO2007/15162; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem