With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.
932-22-9, Synthesis of 4.5-dichloro-2-(2-chlorobenzvnpyridazin-3(2HVone (5) 4 5 To a solution of compound 4 (3 g, 18.2 mmol), compound 2 (4.5 g, 21.8 mmol) and K2coj (5 g, 36.4 mmol) in DMF (30 mL) was added KI (0.3 g, 1.8 mmol). The solution was stirred at 90 C for 2h. The mixture was cooled to room temperature and quenched with water, extracted with EtOAc for 3 times, combined the organic layer, washed with brine, dried over NaaSOi, filtered, concentrated under reduced pressure, purified by column chromatography [eluting with PE to PE/EtOAc (10: 1)] to give compound 5 (5 g, 96 %) as a white solid.
The synthetic route of 932-22-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; BECKWITH, Jonathan Roger; DUTTON, Rachel; ESER, Markus; LANDETA, Cristina; BLAZYK, Jessica L.; MEEHAN, Brian M.; HATAHET, Feras; BOYD, Dana; WO2015/143164; (2015); A1;,
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