19064-67-6, 6-Chloro-3-hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A) 6-Chloro-2-(2-dimethylamino-ethyl)-2H-pyridazin-3-one:To a solution of 6-chloro-pyridazin-3-one (500 mg, 3.83 mmol) in 5 mL N,N- dimethylformamide was added 2-dimethylaminoethyl chloride hydrochloride (828 mg, 5.75 mmol), potassium carbonate (1.59 g, 11.5 mmol) and sodium iodide (632 mg, 4.21 mmol). The mixture was stirred over night at 65 0C. The solvent was evaporated. The crude product was purified by preparative HPLC using a gradient of acetonitrile / 5 % acetonitrile-water phase containing 0.1 M ammonium acetate, to give 174 mg of the desired sub-title product as light brown solids after freeze drying (22 % yield). 1H NMR (400 MHz, methanol-d4 as solvent and internal reference) delta (ppm) 2.35 (s, 6H), 2.82 (t, 2H, J = 6.4 Hz), 4.26 (t, 2H, J = 6.5 Hz), 6.9S (d, IH, J = 9.7 Hz), 7.44 (d, IH. J = 9.7 Hz)., 19064-67-6
The synthetic route of 19064-67-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; WO2007/8144; (2007); A1;,
Pyridazine – Wikipedia
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