With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187973-60-0,6-Iodopyridazin-3-amine,as a common compound, the synthetic route is as follows.
187973-60-0, To a solution of compound 3 (1.00 g, 4.52 mmol) in CH2Cl2(15 mL) was added triethylamine (1.57 mL, 11.31 mmol) and themixture was stirred at 0 C to allow addition of di-tert-butyldicarbonate (1.18 g, 5.43 mmol). The resulting solution was stirredat room temperature overnight (16 h). The solvents were evaporated under reduced pressure. A purification by silica columnchromatography using CH2Cl2 as eluent gave the desired derivative17 (1.13 g, 78%) as a beige solid.Mp 171.7 C. 1H NMR (300 MHz, DMSO-d6) d 7.55 (d, 1H,J 9.3 Hz, H4), 6.56 (d, 1H, J 9.3 Hz, H5), 6.55 (bs, 1H, NH), 3.40 (s,9H, 3 CH3).
187973-60-0 6-Iodopyridazin-3-amine 10867834, apyridazine compound, is more and more widely used in various fields.
Reference£º
Article; Moine, Esperance; Dimier-Poisson, Isabelle; Enguehard-Gueiffier, Cecile; Loge, Cedric; Penichon, Melanie; Moire, Nathalie; Delehouze, Claire; Foll-Josselin, Beatrice; Ruchaud, Sandrine; Bach, Stephane; Gueiffier, Alain; Debierre-Grockiego, Francoise; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 105; (2015); p. 80 – 105;,
Pyridazine – Wikipedia
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