With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20744-39-2,Pyridazin-4-amine,as a common compound, the synthetic route is as follows.
To a suspension of 19b (200 mg, 0.611 mmol), pyridazin-4-amine (58.1 mg, 0.611 mmol) and HATU (232 mg, 0.611 mmol) in DMF (5 mL) was added DIPEA (0.107 mL, 0.611 mmol). The mixture was stirred at room temperature for 16 hrs. The mixture was concentrated and then DCM (15 mL)/ H2O (15 mL) were added. The organic layer was separated and the water phase was extracted with DCM (10 mL¡Á3). The crude was purified by pre-HPLC (acid mobile phase) to give the title compound (23 mg, 0.043 mmol, 7.10 % yield) as a yellow solid. LCMS: 405 [M+H]+. 1H NMR (400 MHz, DMSO-d6): delta 11.39 (s, 1H), 9.28 (br., 2H), 8.39 (d, J= 4.0 Hz, 1H), 7.40-7.54 (m, 4H), 7.29-7.38 (m, 4H), 5.23 (s, 2H), 4.02-4.16 (m, 3H), 3.65 (d, J= 6.8 Hz, 2H), 3.12-3.31 (m, 2H), 0.95 (d, J= 6.0 Hz, 3H). HRMS (ESI): m/z calcd for C23H24N4O3 [M+H]+ 405.1926, found [M+H]+ 405.1926., 20744-39-2
As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.
Reference£º
Article; Ding, Xiao; Stasi, Luigi Piero; Dai, Xuedong; Long, Kai; Peng, Cheng; Zhao, Baowei; Wang, Hailong; Sun, Changhui; Hu, Huan; Wan, Zehong; Jandu, Karamjit S.; Philps, Oliver J.; Chen, Yan; Wang, Lizhen; Liu, Qian; Edge, Colin; Li, Yi; Dong, Kelly; Guan, Xiaoming; Tattersall, F. David; Reith, Alastair D.; Ren, Feng; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 212 – 215;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem