35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(3) N-ethyl 2-propoxy-5-bromobenzylamine hydrochloride 2 (5.17 g, 16.8 mmol) and 3-chloro-6-cyanopyridazine (2.65 g, 16.8 mmol) were dissolved in NMP (25 ml) and sodium hydrogen carbonate added (3.54 g, 42.1 mmol). The mixture was heated at 110 C. under argon for 7.5 hours and then allowed to cool to ambient temperature. The mixture was poured into ethyl acetate (200 ml) washed with water (5*200 ml) and brine (200 ml), the organic phase dried over MgSO4 and concentrated in vacuo. The residue was purified by MPLC (20%ethyl acetate/hexane) and then crystallized from ether/hexane to give the title product (4.80 g, 76%). MS (ESP): 272 (MH+), 227 (M-EtNH2)+. NMR (250 MHz, DMSO-d6) delta: 0.99 (t, J=6 Hz, 3H); 1.26 (t, J=7 Hz, 3H); 1.78 (m, 2H); 2.92 (q, J=7 Hz, 2H); 3.95 (t, J=6 Hz, 2H); 4.02 (s, 2H); 7.02 (d, J=8 Hz, 1H); 7.52 (dd, J=8, 2 Hz, 1H); 7.75 (d, J=2 Hz, 1H); 9.32 (brs, 2H)., 35857-89-7
As the paragraph descriping shows that 35857-89-7 is playing an increasingly important role.
Reference£º
Patent; Zeneca Limited; US5994353; (1999); A;,
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