1122-63-0, 1-(Pyridazin-3-yl)ethanone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1122-63-0, [Referential Example 13] Lithium 1-(6-methoxy-3-pyridyl)-5-(3-pyridazinyl)-1H-pyrazole-3-carboxylate; [Show Image] 1) Methyl 4-(3-pyridazinyl)-2,4-dioxobutanoate; A 1.0M solution of lithium bis(trimethylsilyl)amide in tetrahydrofuran (19 ml) was added dropwise to a solution of 3-acetylpyridazine (2.097 g) in tetrahydrofuran (50 ml) under argon atmosphere at -78C, and the mixture was stirred for 1 hour. A solution of dimethyl oxalate (4.055 g) in tetrahydrofuran (35 ml) was added dropwise to the reaction liquid, and the mixture was stirred at 0C for 2 hours. The reaction solvent was evaporated under reduced pressure, and water and diethylether were added to the residue, then the aqueous layer was separated. The aqueous layer was then acidified with 1N aqueous hydrochloric acid, and the solution was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give methyl 4-(3-pyridazinyl)-2,4-dioxobutanoate (2.63 g, 73%) as a solid. 1H-NMR (400 MHz, CDCl3)delta: 3.97 (3H, s), 7.73 (1H, dd, J = 8.5, 5.1 Hz), 7.96 (1H, s), 8.28 (1H, dd, J = 8.5, 1.8 Hz), 9.38 (1H, dd, J = 5.1, 1.8 Hz). ESI-MSm/z: 209 (M+H)+.
The synthetic route of 1122-63-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1698626; (2006); A1;,
Pyridazine – Wikipedia
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