20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 362-[(Phenylmethyl)oxy]-4-(1 -piperidinylmethyl)- V-4-pyridazinyl-5- (trifluoromethyl)benzamide (E36) To a solution of 2-[(phenylmethyl)oxy]-4-(1-piperidinylmethyl)-5-(trifluoromethyl)benzoic acid (may be prepared as described in Description 53; 112 mg, 0.29 mmol) in N,N- dimethylformamide (5 ml) was added diisopropylethylamine (0.10 ml, 0.57 mmol), 4- pyridazinamine (40.6 mg, 0.43 mmol), 1-hydroxy-7-azabenzotriazole (50.4 mg, 0.37 mmol) and EDC (109 mg, 0.57 mmol). The reaction was stirred for 18 hours, then the solvent removed in vacuo to give a yellow oil. Purification by MDAP gave the title compound as a white solid. 66 mg.MS (electrospray): m/z [M+H]+ 4711 H NMR (DMSO-d6): 1.29 – 1.60 (6 H, m), 2.23 – 2.41 (5 H, m), 3.50 – 3.70 (2 H, m), 5.36 (2 H, s), 7.18 – 7.44 (3 H, m), 7.46 – 7.57 (2 H, m), 7.64 (1 H, s), 7.93 (1 H, s), 8.02 (1 H, dd, J=5.90, 2.64 Hz), 9.08 (1 H, d, J=5.77 Hz), 9.27 (1 H, d, J=2.51 Hz), 10.84 (1 H, s).
20744-39-2, The synthetic route of 20744-39-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem