With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20744-39-2,Pyridazin-4-amine,as a common compound, the synthetic route is as follows.
Example 344-(4-Morpholinylmethyl)-2-[(phenylmethyl)oxy]- V-4-pyridazinyl-5- (trifluoromethyl)benzamide (E34)To a solution of 4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoic acid (may be prepared as described in Description 50; 120 mg, 0.30 mmol) in N,N- dimethylformamide (5 ml) was added diisopropylethylamine (0.11 ml, 0.61 mmol), 4- pyridazinamine (43.3 mg, 0.46 mmol), 1-hydroxy-7-azabenzotriazole (53.7 mg, 0.40 mmol) and EDC (1 16 mg, 0.61 mmol). The reaction was stirred for 3 hours and the solvent was removed in vacuo to give yellow oil. Purification by MDAP gave the title compound as a white solid. 72 mg.MS (electrospray): m/z [M+H]+ 4731 H NMR (DMSO-d6): 2.27 – 2.42 (4 H, m), 3.51 – 3.61 (4 H, m), 3.63 (2 H, s), 5.38 (2 H, s), 7.26 – 7.42 (3 H, m), 7.51 (2 H, d, J=6.78 Hz), 7.62 (1 H, s), 7.94 (1 H, s), 8.03 (1 H, dd, J=5.90, 2.64 Hz), 9.08 (1 H, d, J=5.77 Hz), 9.28 (1 H, d, J=2.01 Hz), 10.85 (1 H, s).
20744-39-2, As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
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