With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-70-5,3-Aminopyridazine,as a common compound, the synthetic route is as follows.,5469-70-5
3-aminopyridazine (lg, 10.5 mmol) is dissolved in toluene (7 mL) and N,N5 dimethylformamide dimethyl acetal (1 .8 mL, 13.67 mmol) is added. The mixture isheated at 65C and stirring is continued overnight. Additional N,N-dimethylformamide dimethyl acetal (1.8 mL, 13.67 mmol) is added and stirring is continued at rt for 3 days. Additional N,N-dimethylformamide dimethyl acetal (3.6 mL, 27.34 mmol) is added and the reaction is heated at 85C for 5h. Volatiles are removed underreduced pressure and the resulting residue is triturated with n-hexane to furnish the title compound (1 .4 g, 91 %)UPLC-MS (Method 2): R = 0.40 mm MS (ESI pos): mlz = 151 (M+H)
The synthetic route of 5469-70-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GIOVANNINI, Riccardo; CUI, Yunhai; DOODS, Henri; FERRARA, Marco; JUST, Stefan; KUELZER, Raimund; LINGARD, Iain; MAZZAFERRO, Rocco; RUDOLF, Klaus; WO2014/184275; (2014); A1;,
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