With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17973-86-3,3,6-Dibromopyridazine,as a common compound, the synthetic route is as follows.
To a mixture of (4-(3-(cyclopropylmethoxy)phenoxy)-2,6-difluorophenyl)methanol (500 mg) and THF (10 ml) was added sodium hydride (60% in oil, 65 mg), and the mixture was stirred at 15C for 30 min. To the mixture was added 3,6-dibromopyridazine (388 mg), and the mixture was stirred at 18C for 4 hr. The reaction mixture was poured into water, and extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (570 mg). 1H NMR (400 MHz, DMSO-d6) delta 0.25-0.35 (2H, m), 0.50-0.60 (2H, m), 1.15-1.25 (1H, m), 3.81 (2H, d, J = 7.2 Hz), 5.47 (2H, s), 6.65-6.73 (2H, m), 6.75-6.85 (3H, m), 7.28 (1H, d, J = 9.2 Hz), 7.34 (1H, t, J = 8.0 Hz), 7.91 (1H, d, J = 9.2 Hz).
17973-86-3, 17973-86-3 3,6-Dibromopyridazine 248852, apyridazine compound, is more and more widely used in various.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; MIZOJIRI, Ryo; ASANO, Moriteru; TOMITA, Daisuke; BANNO, Hiroshi; TAWADA, Michiko; NII, Noriyuki; GIPSON, Krista E.; MAEZAKI, Hironobu; TSUCHIYA, Shuntaro; IMAI, Mayumi; AMANO, Yuichiro; (100 pag.)EP3279183; (2018); A1;,
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