With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90766-97-5,5-Bromo-6-phenylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
90766-97-5, To a solution of 5-bromo-6-phenyl-2,3-dihydropyridazin-3-one (0.700 g, 2.788 mmol) in DMF (12 mL), potassium carbonate (0.462 g, 3.345 mmol) was added followed by 2-bromopropane (0.314 mL, 3.345 mmol) and the resulting mixture heated at 60 C. for 2 h. The mixture was partitioned between EtOAc and water, the aqueous phase was extracted with EtOAc, and the combined organic layers were washed several times with brine. The organic phase was dried over sodium sulfate and the solvent was removed. The crude was purified by flash chromatography on silica gel Biotage cartridge (cyclohexane to cyclohexane_EtOAc=85:15) to afford title compound as a pale yellow solid (0.630 g, 2.149 mmol, 77% yield). MS/ESI+ 293.1-295.1 [MH]+, Rt=1.11 min (Method A).
90766-97-5 5-Bromo-6-phenylpyridazin-3(2H)-one 2767911, apyridazine compound, is more and more widely used in various.
Reference£º
Patent; CHIESI FARMACEUTICI S.p.A.; BIAGETTI, Matteo; Capelli, Anna Maria; Guala, Matilde; (42 pag.)US2016/75710; (2016); A1;,
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