932-22-9, 4,5-Dichloro-3(2H)-pyridazinone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,932-22-9
To a solution of 4,5-dichloro-1H-pyridazin-6-one (5 g, 30.31 mmol, 1 eq) in dimethylsulfoxide (100 mL) was added diisopropylethylamin (11.75 g, 90.92 mmol, 3 eq) and tert-butyl piperazine-1-carboxylate hydrochloride (6.75 g, 30.31 mmol, 1 eq). The mixture was stirred at 120 C. for 3 hours. The resulting mixture was cooled to room temperature, filtered and quenched by addition of water (500 mL), then extracted with ethyl acetate (100 mL*3). The combined organic phase was washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduce pressure. The residue was purified by silica gel chromatography (dichloromethane: methyl alcohol=200:1 to 100:1). Tert-butyl 4-(5-chloro-6-oxo-1H-pyridazin-4-yl)piperazine-1-carboxylate (8.18 g, 24.95 mmol, 82% yield, 96% purity) was obtained as a yellow solid. LC/MS (ESI) m/z: 315.1 [M+1]+; 1H NMR (400 MHz, CDCl3) delta 11.95 (s, 1H), 7.66 (s, 1H), 3.64-3.57 (m, 4H), 3.44-3.36 (m, 4H), 1.49 (s, 9H).
As the paragraph descriping shows that 932-22-9 is playing an increasingly important role.
Reference£º
Patent; Arvinas, Inc.; Crew, Andrew P.; Berlin, Michael; Dong, Hanqing; Homberger, Keith R.; Qian, Yimin; Snyder, Lawrence B.; Wang, Jing; Zimmermann, Kurt; (504 pag.)US2018/215731; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem