With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123696-01-5,5-Methoxypyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.,123696-01-5
0500-1 A mixture of 5-methoxypyridazin-3(2H)-one (2.35 g), phosphoryl bromide (16.0 g), and acetonitrile (90 mL) was stirred for 6 hour under reflux. The reaction mixture was added dropwise to a sodium carbonate aqueous solution under ice-cooling, and ethyl acetate was added thereto. The organic layer was collected by separation, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel chromatography (ethyl acetate-hexane), thereby obtaining 3,5-dibromopyridazine (1.67 g). MS m/z (M+H): 237.
The synthetic route of 123696-01-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FUJIFILM Corporation; FURUYAMA, Hidetomo; KURIHARA, Hideki; TERAO, Takahiro; NAKAGAWA, Daisuke; TANABE, Shintaro; KATO, Takayuki; YAMAMOTO, Masahiko; SEKINE, Shinichiro; MASHIKO, Tomoyuki; INUKI, Shinsuke; UEDA, Satoshi; US2015/322063; (2015); A1;,
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