With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1837-55-4,3,5-Dichloropyridazine,as a common compound, the synthetic route is as follows.,1837-55-4
A suspension of 3,5-dichloropyridazine (0.400 g, 2.68 mmol), methyl 5-(4,4,5,5-tetramethyl-1 ,3,2-dioxa-borolan-2-yl)thiophene-2-carboxylate (0.720 g, 2.68 mmol) and KF (0.3909, 6.71 mmol) in toluene (15mL) and water (3 mL) was degassed with Ar for 10 mi Palladium(ll) acetate (0.030 g, 0.13 mmol) and1,2,3,4,5-pentaphenyl-1?-(di-ted-butylphosphino)ferrocene (0.095 g, 0.13 mmol) were added and the mixture was degassed with Ar for 3 more mm, then heated at 70 C for 18 h. The mixture was filteredover Celite. The filtrate was concentrated under reduced pressure and purified by FC (EtOAc/heptane1:19 -* 2:3) to obtain methyl 5-(6-chloropyridazin-4-yl)thiophene-2-carboxylate (0.300 g, 85%, w/w, 1.00mmol, 37%). LCMS: cal for [M+HJ = 254.99, fd 255.0.
The synthetic route of 1837-55-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GRUeNENTHAL GMBH; NARDI, Antonio; RATCLIFFE, Paul; CRAAN, Tobias; HERTRAMPF, Thorsten; LESCH, Bernhard; STEINHAGEN, Henning; (70 pag.)WO2015/161924; (2015); A1;,
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