With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10344-42-0,4-Bromo-3,6-dichloropyridazine,as a common compound, the synthetic route is as follows.
c) 3,6-Dichloro-4-(3,6-dihydro-2H-pyridin-1-yl)pyridazine 1,2,3,6-Tetrahydropyridine, (1.04 ml) was added to a stirred solution/suspension of 4-bromo-3,6-dichloropyridazine (2.0 g, 8.8 mmol) and potassium carbonate (2.4 g) in dry DMF (10 ml) at room temperature under nitrogen. The mixture was stirred at room temperature for 5 hours. The reaction was poured into water (100 ml) and extracted with ethyl acetate (*3). The combined extracts were washed with water (200 ml), brine, dried (MgSO4), filtered and evaporated. The residue was triturated with ether/petroleum ether to afford a white powder (1.96 g, 97%). 1H NMR (250 MHz, CDCl3) 6.82 (1H, s), 5.97 (1H, m), 5.80 (1H, m), 3.77 (2H, m), 3.59 (2H, m), 2.38 (2H, m). MS (ES+) 232 [MH]+.
10344-42-0 4-Bromo-3,6-dichloropyridazine 22030648, apyridazine compound, is more and more widely used in various.
Reference£º
Patent; Merck Sharp & Dohme Ltd.; US6319924; (2001); B1;,
Pyridazine – Wikipedia
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