With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.
Add trichloroisocyanuric acid (0.189 g) to a solution of 3-chloro-6-methylpyridazine (0.208 g) in chloroform (10 mL). Heat the oil bath to 60 C, lasts for 12 hours. Cool to room temperature, the filtrate was collected by filtration. Concentrated and purified by column chromatography (PE/EA=10/1). 0.201 g of 3-chloro-6-(chloromethyl)pyridazine was obtained.
The synthetic route of 1121-79-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BetaEpsilonTauTauAlpha PHARMACEUTICALS CO., LTD; WANG, YIQIAN; WANG, JIABING; DING, LIEMING; (80 pag.)TW2018/29406; (2018); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem