With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
Example 6 Synthesis of 2-tert.-butyl-4-chloro-5-[4-(1,1,2-trifluoro-2-trifluoromethoxy-ethoxy)-alpha-methyl-benzyloxy]-3(2H)-pyridazinone [Compound (1)] 1.5 g of 4-(1,1,2-trifluoromethoxy-ethoxy)-alpha-methylbenzyl alcohol (Example 1) were added to a suspension of 0.24 g of sodium hydride (50% in 10 ml of formaldehyde) and 15 minutes later 1.1 g of 2-tert.-butyl-4,5-dichloro-3(2H)-pyridazinone were added to the resulting mixture. The reaction mixture was stirred for 1 hour at room temperature, diluted with ether and washed with diluted HCl and brine. The washed solution was thoroughly dried, the solvent was evaporated and the crude reaction product thus obtained was chromatographed on silica gel with 9/1 hexane/ethyl acetate. Thus 0.9 g of pure product were obtained.
The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MINISTERO DELL’ UNIVERSITA’ E DELLA RICERCA SCIENTIFICA E TECNOLOGICA; EP391390; (1990); A1;,
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