With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.
To 3,4,5-trichloropyridazine (1.624 g, 8.85 mmol) and N-ethyl-N-isopropylpropan-2-amine (2.289 g, 17.71 mmol) in 50 mL N,N-dimethylformamide at 0 C. was added tert-butyl 4-(4-(azetidine-3-carboxamido)phenylsulfonyl)piperidine-1-carboxylate (2.5 g, 5.90 mmol) in ml N,N-dimethylformamide, dropwise. The reaction mixture was stirred from 0 C. to room temperature overnight, diluted with water and extracted with ethyl acetate. The organic layer was dried with magnesium sulfate, filtered, concentrated and purified by flash chromatography to give the title compound.
As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.
Reference£º
Patent; ABBVIE INCORPORATED; HANSEN, TODD M; LONGENECKER, KENTON; HEYMAN, HOWARD R; CURTIN, MICHAEL L; CLARK, RICHARD F; SORENSEN, BRYAN; JI, ZHIQIN; DOHERTY, GEORGE; FREY, ROBIN; WOLLER, KEVIN; (600 pag.)JP2015/520752; (2015); A;,
Pyridazine – Wikipedia
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