With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.
A mixture of 3,4,5-trichloropyridazine (1 g, 5.45mmol), 4-phenylpiperidine (0.9 g, 5.58 mmol) and potassium carbonate (1.5 g, 10.85mmol) in acetonitrile (25 ml) was stirred for 4 days. The mixture was diluted withethyl acetate and water. The ethyl acetate layer was separated, washed with water, dried with brine, and concentrated to a red-brown solid. The solid was dissolved in dioxane (25 ml) and 35% hydrazine (10 ml, 110 mmol) was added. The mixture was heated to reflux for 16 hr overnight. The mixture was diluted with ethyl acetate andwater. The ethyl acetate layer was separated, washed twice with water, dried with brine, and separated. The ethyl acetate layer was placed into a 250 ml flask with saturated sodium carbonate (15 ml). A solution of 2-cyclopropylacetyl chloride (freshly prepared from 2-cyclopropylacetic acid (0.600 g, 6.00 mmol) and thionyl chloride) in ethyl acetate (25 ml) was added and the mixture was stirred for 16 h.
As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
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