With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-63-0,1-(Pyridazin-3-yl)ethanone,as a common compound, the synthetic route is as follows.
Triisopropylsilyl triflate (26.4 g) is added over 4 min. to an ice cooled solution [OF 3-] acetylpyridazine (9.57 g) and diisopropylethylamine [(30.] 4 g) in dry [CH2C12] [(100 ML)] under nitrogen. After 4 h, the solvent is evaporated and the residue extracted with diethyl ether (150 mL). The organic layer is washed with saturated aq. sodium bicarbonate solution (2 [X] [60] mL) followed by brine (60 [ML),] dried [(MGSO4),] filtered and evaporated.. The crude product is purified by column chromatography [(HEXANES/ETOAC,] 9/1) to afford 13.4 g of the title compound as a yellow oil. Physical [CHARACTERISTICS. 1H NMR (400 MHz, CDCl3) delta 9.10, 7.85, 7.52, 5.98, 4.74, 1.35, 1.16 ; HRMS (ESI) m/z 279.1879
The synthetic route of 1122-63-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; FLECK, Bruce, Francis; WO2004/22567; (2004); A1;,
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