35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of N4-((3R,65)-6-aminohexahydrofuro[3,2-*]furan-3-yl)-5-chloro-N2-(l- methyl-lH-pyrazol-4-yl)pyrimidine-2,4-diamine (32 mg, 0.091 mmol) in butan-l-ol (20 mL) were added 6-chloropyridazine-3-carbonitrile (25 mg, 0.179 mmol) and triethylamine (42 mg, 0.415 mg). The reaction was stirred at 120 C for 20 hours and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/30) to give the title compound as a yellow solid (17 mg, 0.037mmol, yield 41%). LC-MS (ESI, pos. ion) m/z: 455.4 [M+H]+;1H NMR (400 MHz, CDCh) delta (ppm): 7.81 (s, 1H), 7.55 (s, 1H), 7.48 (s, 1H), 7.40 (d, J = 9.1 Hz, 1H), 6.78 (d, J = 9.3 Hz, 1H), 4.71 (s, 1H), 4.64-4.57 (m, 3H), 4.24-4.14 (m, 2H), 4.00-3.96 (m, 1H), 3.81 (s, 3H), 3.69-3.66 (m, 3H).
The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem