With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20074-67-3,Perchloropyridazine,as a common compound, the synthetic route is as follows.
Weigh 0.4 g (1.22 mmol) of intermediate 6, 0.044 g (0.20 mmol) of 3,4,5,6-tetrachloropyridazine, 2.6 g (12.2 mmol) of tripotassium phosphate, 0.007 g (0.006 mmol) of tetrakis(triphenylphosphine)palladium in 100 ml dried two-necked flask was charged with 50 mL (toluene:ethanol=5:1) as a reaction solvent, under nitrogen, and heated to 80 C for 20 hours. After completion of the reaction, the solvent was extracted under reduced pressure and extracted with dichloromethane (25 mL x 3). The extracts were combined and dried over anhydrous magnesium sulfate. The solvent was dried and dried. The crude product was treated with petroleum ether and dichloromethane (PE:DCM=15:1) And the column was purified by column chromatography to obtain 0.21 g of a pale yellow crystalline powder, Yield 84.2%.
The synthetic route of 20074-67-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Dalian University of Technology; LI, JIUYAN; SUI, KAI; LIU, DI; (19 pag.)CN106243091; (2016); A;,
Pyridazine – Wikipedia
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