With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16401-70-0,N-Methylpyridazin-4-amine,as a common compound, the synthetic route is as follows.
A solution of 594 mg 5-methyl-1 -(1 -spiro[2.2]pentan-5-ylethyl)pyrazole-4-carbonyl chloride in 5 mL THF was added dropwise to a solution of 271 mg N-methylpyridazin-4-amine and 315 mg triethylamine in 30 mL THF at 0C. The mixture was stirred at 20-25C for about 20 h, the solvent was evaporated and the residue was diluted with 70 mL dichloromethane, washed with 2 10 mL water, dried over MgSC and evaporated. Purification by flash chromatography (CH2CI2/MeOH) gave 522mg of the title compound. HPLC-MS: RT 0.842 min, m/z [MH]+ 312.2
The synthetic route of 16401-70-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BASF SE; BASF SCHWEIZ AG; SOeRGEL, Sebastian; SAeLINGER, Daniel; DEFIEBER, Christian; LANGEWALD, Juergen; GOCKEL, Birgit; HADEN, Egon; CULBERTSON, Deborah L.; GUNJIMA, Koshi; WO2013/189801; (2013); A1;,
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