372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (581 mg, 2.81 mmol),4-morpholinoaniline 92c (500mg, 2.81mmol),Diisopropylethylamine (3.63 g, 28 mmol) and acetonitrile (10 mL) were mixed, heated to 90 C and stirred for 18 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 100/0 to 1/4),The target product 6-chloro-4-((4-morpholinophenyl) amino) pyridazine-3-carboxylic acid methyl ester 92d (768 mg, brown solid) was obtained in a yield of 78%.
The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
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