88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[00268] To a solution of amino-heterocycle derivative (1 eq.) in nBuOH under argon are added successively the aldehyde RzCHO (2.5 eq.), MgC^ (0.04 eq.) and 1,1,3,3-tetramethylbutyl isocyanide (1.15 eq.). The reaction mixture is heated at 130 C from between 3.5 h to overnight, and then concentrated in vacuo. The residue is partitioned between heptane and water, stirred for 15 to 40 min, the biphasic solution is filtered on Celpure P65, and the cake is washed with heptane. The two layers of the filtrate are separated, the organic layer is washed successively with water, an aqueous 1M NaOH and brine, then dried over Na2S04 and concentrated in vacuo to afford the expected amine which is used directly in the next step.
The synthetic route of 88497-27-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GALAPAGOS NV; DESROY, Nicolas; HECKMANN, Bertrand; BRYS, Reginald Christophe Xavier; JONCOUR, Agnes Marie; PEIXOTO, Christophe; BOCK, Xavier Marie; HOUSSEMAN, Christopher Gaetan; WO2014/202458; (2014); A1;,
Pyridazine – Wikipedia
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